Whi5 Regulation by Site Specific CDK Phosphorylation in Saccharomyces Cerevisiae

Whi5 Regulation by Site Specific CDK Phosphorylation in Saccharomyces Cerevisiae

4.11 - 1251 ratings - Source



The Whi5 transcriptional repressor is a negative regulator of G1 cell cycle progression in Saccharomyces cerevisiae and is functionally equivalent to the retinoblastoma (Rb) tumor suppressor protein in mammals. In early G1, Whi5 binds to and inhibits SBF (Swi4/Swi6) transcriptional complexes. At Start, Cln:Cdc28 kinases phosphorylate and inactivate Whi5, causing its dissociation from SBF promoters and nuclear export, allowing activation of SBF transcription and entry into the cell cycle. Due to the conserved regulatory pathways controlling G1 transcription between yeast and mammalian cells, investigation into the regulation by phosphorylation of Whi5 in yeast could provide insight into mammalian G1 cell cycle and Rb regulation.Model of yeast G1 cell cycle progression. genes, suggesting there is overlap in the specificity of SBF ... RNR1, POL2 CLB5, CLB6 DNA Replication Genes DNA Repair Genes IMCBI Repressed ROS Cyclin D:Cdk4/6 T p16 1 p27 Cyclin E: Cdk2anbsp;...


Title:Whi5 Regulation by Site Specific CDK Phosphorylation in Saccharomyces Cerevisiae
Author:
Publisher:ProQuest - 2008
ISBN-13:

You must register with us as either a Registered User before you can Download this Book. You'll be greeted by a simple sign-up page.

Once you have finished the sign-up process, you will be redirected to your download Book page.

How it works:
  • 1. Register a free 1 month Trial Account.
  • 2. Download as many books as you like (Personal use)
  • 3. Cancel the membership at any time if not satisfied.


Click button below to register and download Ebook
Privacy Policy | Contact | DMCA