A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.ANSHU AGRAWAL, PhD ac Department of Pathology, Emory Vaccine Center, Emory University, Atlanta, GA SUDHANSHU AGRAWAL, Department of Pathology, Emory Vaccine Center, Emory University, Atlanta, GA SHIZUO AKIRA, MD, PhDanbsp;...
Title | : | Vaccine Adjuvants |
Author | : | Charles J. Hackett, Donald A. Harn Jr |
Publisher | : | Springer Science & Business Media - 2007-11-05 |
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